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Methotrexate History

Methotrexate Abortion

Methotrexate was discovered around the time of WWII. Sidney Farber at Children's Hospital Boston tested the effects of folic acid several types of cancer. Researchers studying methotrexate at the company Lederle started looking for drugs that resembled folic acid. This research led to the discovery of methotrexate. It was finally developed for use in 1948. Methotrexate received FDA approval drug in 1953. Since that time it has been used worldwide for a variety of medical interventions.

During the 1980's and 1990's many studies were done with methotrexate to see if it could stop the growth of a tubal or ectopic pregnancy.

Ectopic pregnancy account for 1-3% of all pregnancies and threaten the life of the woman. If the ectopic or tubal pregnancy ruptures a women may die from internal bleeding if it is not diagnosed and treated in time.

Prior to the use of Methotrexate, women diagnosed with ectopic pregnancies underwent a surgery called a laparoscopic salpingostomy. This was an intrusive surgery, but was often necessary to save the patient's life.

In the proper setting, researchers discovered that Methotrexate could be given in a safe fashion and the Ectopic cured without surgery.

Further research found that methotrexate could also be used to induce a chemical abortion. A small percentage of the cases required further intervention. However, the vast majority were successful and avoided the need for surgical abortion. The benefit of a Methotrexate induced abortion is that if there is a unknown tubal pregnancy it often will be treated.

Discuss Methotrexate induced abortion with your health care provider for definitive information. Methotrexate can only be counseled and administered under the supervision of a well trained health care individual.

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